LINKAGE ANALYSIS OF THE HUMAN HMG14 GENE ON CHROMOSOME-21 USING A GT DINUCLEOTIDE REPEAT AS POLYMORPHIC MARKER

被引：59

作者：

PETERSEN, MB

ECONOMOU, EP

SLAUGENHAUPT, SA

CHAKRAVARTI, A

ANTONARAKIS, SE

机构：

[1] UNIV PITTSBURGH,WESTERN PSYCHIAT INST & CLIN,DEPT HUMAN GENET,PITTSBURGH,PA 15213

[2] UNIV PITTSBURGH,WESTERN PSYCHIAT INST & CLIN,DEPT PSYCHIAT,PITTSBURGH,PA 15213

来源：

GENOMICS | 1990年 / 7卷 / 01期

关键词：

D O I：

10.1016/0888-7543(90)90531-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A (GT)n repeat in intron 4 of the functional human HMG14 gene on chromosome 21 was used as polymorphic marker to map this gene relative to the genetic linkage map of human chromosome 21. Variation in the length of the (GT)n repeat was detected by electrophoresis on polyacrylamide gels of DNA amplified by the polymerase chain reaction using primers flanking the repeat. The observed heterozygosity of this polymorphism in 40 CEPH families was 58% with six different alleles. Linkage analysis localized the HMG14 gene close to the ETS2 gene and locus D21S3 in chromosomal band 21q22.3. © 1990.

引用

页码：136 / 138

页数：3

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