NGF ENHANCES NEURITE REGENERATION FROM NERVE-TRANSECTED TERMINALS OF YOUNG-ADULT AND AGED MOUSE DORSAL-ROOT GANGLIA INVITRO

被引：51

作者：

HORIE, H

BANDO, Y

CHI, H

TAKENAKA, T

机构：

[1] Department of Physiology, School of Medicine, Yokohama City University, Yokohama

来源：

NEUROSCIENCE LETTERS | 1991年 / 121卷 / 1-2期

关键词：

REGENERATION; NERVE TRANSECTION; DORSAL ROOT GANGLION; NERVE GROWTH FACTOR; INVITRO; AGED MOUSE;

D O I：

10.1016/0304-3940(91)90665-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dorsal root ganglia with nerve fibers, dissected from 3-month-old young adult mice and 26-month-old aged mice, were embedded in collagen gel. In the young adult mice regenerating neurites appeared from nerve-transected terminals after 12-24 h in culture, regardless of the length of fibers, but in the aged mice, regenerating neurites were first seen after 12-48 h. Administration of nerve growth factor to the explants markedly enhanced the growth of regenerating neurites from both the young adult and aged mice.

引用

页码：125 / 128

页数：4

共 19 条

[1] COMPARISON OF THE SCHWANN-CELL SURFACE AND SCHWANN-CELL EXTRACELLULAR-MATRIX AS PROMOTERS OF NEURITE GROWTH [J].