INHIBITION OF PHTHALOCYANINE-SENSITIZED PHOTOHEMOLYSIS OF HUMAN ERYTHROCYTES BY QUERCETIN

被引:18
作者
BENHUR, E
ROSENTHAL, I
GRANOT, Y
机构
[1] AGR RES ORG,VOLCANI CTR,DEPT FOOD SCI,POB 6,IL-50250 BET DAGAN,ISRAEL
[2] NEW YORK BLOOD CTR,NEW YORK,NY 10021
[3] BEN GURION UNIV NEGEV,DEPT LIFE SCI,BEER SHEVA,ISRAEL
关键词
D O I
10.1111/j.1751-1097.1993.tb02959.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Photohemolysis of erythrocytes in the presence of aluminum phthalocyanine tetrasulfonate as a sensitizer is inhibited by quercetin. D2O (98.5%) stimulated photohemolysis regardless of quercetin presence, suggesting the participation of singlet oxygen in the process. Since it has been shown that this flavonoid reacts with singlet oxygen, the protective effect might be attributed, at least partially, to its competitive reaction with singlet oxygen. At the molecular level, the alterations of membrane proteins that escort the process of photohemolysis, such as cross-linking of spectrin monomers and of other membrane proteins, were selectively inhibited by quercetin. This effect was qualitatively similar to that induced by NaF, suggesting that quercetin may, like NaF, also inhibit type I photooxidations, which contribute to hemolysis. The lipophilicity of quercetin seems to be an essential factor in the inhibition process; rutin, a water-soluble 3-rutinoside of quercetin, had only a negligible protective effect on photohemolysis.
引用
收藏
页码:984 / 988
页数:5
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