POSTTREATMENT WITH AMINO-COMPOUNDS EFFECTIVE IN PREVENTION OF CALCIFICATION OF GLUTARALDEHYDE TREATED PERICARDIUM

被引：21

作者：

CHANDA, J ^{[1
]}

机构：

[1] SREE CHITRA TIRUNAL INST MED SCI & TECHNOL,DEPT CARDIOVASC SURG,TRIVANDRUM,INDIA

来源：

ARTIFICIAL ORGANS | 1994年 / 18卷 / 05期

关键词：

BIOPROSTHETIC HEART VALVE; GLYCINE-ALBUMIN; GENTAMICIN; PERICARDIUM; GLUTARALDEHYDE; CALCIFICATION;

D O I：

10.1111/j.1525-1594.1994.tb02223.x

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An attempt has been made to compare the role of different amino compounds in prevention of calcification of glutaraldehyde (GA)-treated pericardium implanted subcutaneously in the rat for 12 weeks. GA pretreated pericardial samples were postfixed separately with glycine, albumin, gentamicin, glycine + gentamicin, and albumin + gentamicin. Severe calcification was noticed in animals undergoing albumin or gentamicin post-fixation. Mild calcification was observed in glycine and albumin + gentamicin postfixed materials whereas calcium was undetectable either chemically or morphologically in GA-pretreated pericardium postfixed with glycine + gentamicin (0.32 +/- 0.13 mg/g calcium, dry wt; von Kossa 0) at the 12th week of implantation in the rat.

引用

页码：408 / 410

页数：3

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