CONVERSION OF ONE ENANTIOMER OF THE CARBOCYCLIC NUCLEOSIDE SYNTHON 2-AZABICYCLO[2.2.1]HEPT-5-EN-3-ONE INTO THE OTHER

被引：9

作者：

PALMER, CF

MCCAGUE, R

机构：

[1] Chiroscience Ltd., Cambridge CB4 4WE, Cambridge Science Park, Milton Road

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 10期

关键词：

D O I：

10.1039/p19950001201

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The lactam synthon 2-azabicyclo[2.2.1]hept-5-en-3-one was converted into its enantiomer by a 5-step sequence incorporating a skeletal rearrangement mediated by anchimeric assistance of the nitrogen atom; the route proceeded via a tosylate intermediate prone to racemization.

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页码：1201 / 1203

页数：3

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