BCR-ABL - AN ANTI-APOPTOSIS GENE IN CHRONIC MYELOGENOUS LEUKEMIA

被引：34

作者：

COTTER, TG

机构：

[1] Department of Biochemistry, University College, Cork

来源：

LEUKEMIA & LYMPHOMA | 1995年 / 18卷 / 3-4期

关键词：

APOPTOSIS; LEUKEMIA; BCR-ABL;

D O I：

10.3109/10428199509059612

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The expression of bcr-abl in chronic myelogenous leukemia leads to a large increase in the generation of mature myeloid cells. The key biochemical alteration in this disease is an increased Abl kinase activity, This up-regulation in activity is mediated through the binding of a portion of the Bcr molecule to the SH2 regulatory domain of the Abl protein. One effect of this alteration is a marked increase in resistance to drug induced cell death by apoptosis. This resistance can be overcome with the use of appropriate antisense oligonucleotides to the bcr-abl gene. The role and contribution of apoptosis to the development of the disease and the prospect of using antisense oligonucleotides as therapeutic agents is discussed.

引用

页码：231 / 236

页数：6

共 32 条

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