ON THE USE OF THE MOMENTS METHOD OF ESTIMATION TO OBTAIN APPROXIMATE MAXIMUM-LIKELIHOOD-ESTIMATES OF LINKAGE BETWEEN A GENETIC-MARKER AND A QUANTITATIVE LOCUS

被引：10

作者：

DARVASI, A ^{[1
]}

WELLER, JI ^{[1
]}

机构：

[1] AGR RES ORG,VOLCANI CTR,INST ANIM SCI,IL-50250 BET DAGAN,ISRAEL

来源：

HEREDITY | 1992年 / 68卷

关键词：

GENETIC MARKERS; MOMENTS METHOD; MAXIMUM LIKELIHOOD; QUANTITATIVE TRAIT LOCI;

D O I：

10.1038/hdy.1992.5

中图分类号：

Q14 [生态学（生物生态学）];

学科分类号：

071012 ; 0713 ;

摘要：

The approximate maximum likelihood method of Luo & Kearsey (1989) to determine the parameters of a segregating quantitative trait locus (QTL) in an F2 population by linkage to a genetic marker is compared to the 'true' maximum likelihood estimates derived by scanning the seven parameter likelihood space. The two methods did not yield identical results, and diverged markedly for a dominant QTL loosely linked to the genetic marker. Further study is suggested to evaluate other methods that do not simultaneously maximize the likelihood for all parameters.

引用

页码：43 / 46

页数：4

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