ALLOPURINOL PRODRUGS .2. SYNTHESIS, HYDROLYSIS KINETICS AND PHYSICOCHEMICAL PROPERTIES OF VARIOUS N-ACYLOXYMETHYL ALLOPURINOL DERIVATIVES

被引:16
作者
BUNDGAARD, H [1 ]
FALCH, E [1 ]
机构
[1] ROYAL DANISH SCH PHARM,DEPT CHEM BC,DK-2100 COPENHAGEN,DENMARK
关键词
D O I
10.1016/0378-5173(85)90030-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:307 / 325
页数:19
相关论文
共 38 条
[1]  
ALBERT A, 1971, DETERMINATION IONIZA
[2]  
APPELBAUM SJ, 1980, DRUG INTEL CLIN PHAR, V14, P789
[3]   ALLOPURINOL KINETICS AND BIOAVAILABILITY - INTRAVENOUS, ORAL AND RECTAL ADMINISTRATION [J].
APPELBAUM, SJ ;
MAYERSOHN, M ;
DORR, RT ;
PERRIER, D .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1982, 8 (01) :93-98
[4]   N-HYDROXYMETHYL DERIVATIVES OF NITROGEN-HETEROCYCLES AS POSSIBLE PRODRUGS .2. POSSIBLE PRODRUGS OF ALLOPURINOL, GLUTETHIMIDE, AND PHENOBARBITAL [J].
BANSAL, PC ;
PITMAN, IH ;
HIGUCHI, T .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1981, 70 (08) :855-857
[5]   STUDIES ON THE CHEMICAL-REACTIVITY AND THE PHYSICAL-PROPERTIES OF ALLOPURINOL (PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE) AND RELATED COMPOUNDS [J].
BERGMANN, F ;
FRANK, A ;
NEIMAN, Z .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1979, (11) :2795-2802
[6]  
BODOR N, 1981, Drugs of the Future, V6, P165
[7]  
BODOR N, 1979, Patent No. 4160009
[8]   A SIMPLIFIED HIGH-PRESSURE LIQUID-CHROMATOGRAPHY METHOD FOR DETERMINING LIPOPHILICITY FOR STRUCTURE ACTIVITY RELATIONSHIPS [J].
BRENT, DA ;
SABATKA, JJ ;
MINICK, DJ ;
HENRY, DW .
JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (07) :1014-1020
[9]   ALLOPURINOL PRODRUGS .1. SYNTHESIS, STABILITY AND PHYSICOCHEMICAL PROPERTIES OF VARIOUS N-1-ACYL ALLOPURINOL DERIVATIVES [J].
BUNDGAARD, H ;
FALCH, E .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1985, 23 (02) :223-237
[10]   PRO-DRUGS AS DRUG DELIVERY SYSTEMS .8. BIOREVERSIBLE DERIVATIZATION OF HYDANTOINS BY N-HYDROXYMETHYLATION [J].
BUNDGAARD, H ;
JOHANSEN, M .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1980, 5 (01) :67-77