PHARMACOLOGICAL INHIBITION OF PROGRAMMED LYMPHOCYTE DEATH

被引：75

作者：

KROEMER, G ^{[1
]}

MARTINEZ, C ^{[1
]}

机构：

[1] UNIV AUTONOMA MADRID, CSIC, E-28049 MADRID, SPAIN

来源：

IMMUNOLOGY TODAY | 1994年 / 15卷 / 05期

关键词：

D O I：

10.1016/0167-5699(94)90249-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Programmed cell death (PCD) is a necessary process that helps to regulate the lifespan of lymphocytes and maintain the compartmental balance of lymphoid organs. In addition, PCD is required for the generation and maintenance of self-tolerance. strategies that inhibit PCD cause profound alterations in the (patho)physiology of the immune system. Here, Guido Kroemer and Carlos Martinez-A. discuss the multiplicity of PCD-inducing pathways, which have been revealed through the use of PCD-inhibitory agents, and analyse the levels at which these agents act.

引用

页码：235 / 242

页数：8

共 75 条

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