LINKAGE ANALYSIS OF ALZHEIMERS-DISEASE WITH METHODS USING RELATIVE PAIRS

被引：3

作者：

BLOSSEY, H

COMMENGES, D

OLSON, JM

机构：

[1] UNIV WASHINGTON,DEPT BIOSTAT,SEATTLE,WA 98195

[2] UNIV BORDEAUX 2,INSERM,U330,F-33076 BORDEAUX,FRANCE

来源：

GENETIC EPIDEMIOLOGY | 1993年 / 10卷 / 06期

关键词：

AFFECTED SIB PAIR METHODS; HASEMAN-ELSTON METHOD; LINKAGE; SCORE TEST; ALZHEIMERS DISEASE;

D O I：

10.1002/gepi.1370100608

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Four relative-pair methods for detecting genetic linkage were applied to familial Alzheimer's disease data. Results obtained using an extended Haseman-Elston test and a weighted rank pairwise correlation test, which both use information from all relative pairs, were consistent with previously published likelihood results and appear to be more powerful than affected sib pair methods. (C) 1993 Wiley-Liss, Inc.

引用

页码：377 / 382

页数：6

共 13 条

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