INCREASED TISSUE ENDOTHELIN IMMUNOREACTIVITY IN ATHEROSCLEROTIC LESIONS ASSOCIATED WITH ACUTE CORONARY SYNDROMES

被引：92

作者：

ZEIHER, AM ^{[1
]}

IHLING, C ^{[1
]}

PISTORIUS, K ^{[1
]}

SCHACHINGER, V ^{[1
]}

SCHAEFER, HE ^{[1
]}

机构：

[1] UNIV FREIBURG,DEPT PATHOL,D-79106 FREIBURG,GERMANY

来源：

LANCET | 1994年 / 344卷 / 8934期

关键词：

D O I：

10.1016/S0140-6736(94)90571-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute coronary syndromes are accompanied by exaggerated vasoconstriction. Since thrombin induces production of the potent vasoconstrictor endothelin-1, we used immunohistochemistry on coronary atherosclerotic specimens from 30 consecutive patients. Endothelin-1-like immunoreactivity was present in 5 of 9 (55%) lesions from patients with stable angina, in 6 of 7 (86%) from crescendo angina, and in all 14 from angina at rest. Endothelin-1 immunoreactivity was most common in areas with a positive Prussian-blue reaction indicative of previous intraplaque haemorrhage. Tissue endothelin-1-like immunoreactivity might contribute to the exaggerated coronary vasoconstriction.

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页码：1405 / 1406

页数：2

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