STERIC ACCELERATION OF INTRAMOLECULAR OXIME AND HYDRAZONE CYCLOADDITIONS

被引：11

作者：

BISHOP, JE

FLAXMAN, KA

ORLEK, BS

SAMMES, PG

WELLER, DJ

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT, DEPT MED CHEM, HARLOW CM19 5AD, ESSEX, ENGLAND

[2] BRUNEL UNIV, DEPT CHEM, MOLEC PROBES UNIT, UXBRIDGE UB8 3PH, MIDDX, ENGLAND

[3] WHITBREAD PLC, WHITBREAD TECH CTR, LUTON LU1 3ET, BEDS, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 20期

关键词：

D O I：

10.1039/p19950002551

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Selected Conformational constraints, achieved by the incorporation of ortho-substituents in 2-substituted 1-allyloxybenzenes, where the substituent is a 1,3-dipole or its tautomeric precursor, as in oximes, can be employed to accelerate the 1,3-dipolar cycloaddition process. Some evidence that hydrazones preferentially react with the alkene group by prior oxidation to the corresponding nitrilimine species is presented.

引用

收藏

页码：2551 / 2555

页数：5

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