INFLUENCE OF PHENOBARBITAL ON BIOTRANSFORMATION OF 25-HYDROXYCHOLECALCIFEROL

被引：8

作者：

BURT, R ^{[1
]}

FRESTON, JW ^{[1
]}

TOLMAN, KG ^{[1
]}

机构：

[1] UNIV UTAH, COLL MED, DEPT INTERN MED, DIV GI, SALT LAKE CITY, UT 84132 USA

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 1976年 / 16卷 / 8-9期

关键词：

D O I：

10.1002/j.1552-4604.1976.tb02413.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of phenobarbital on the biotransformation of 25-OHD3 [25-hydroxycholecalciferol] to 1,25-(OH)2-D3 [1,25-dihydroxycholecalciferol] was studied in rats. The disappearance rate of 25-OHD3 was virtually the same in the phenobarbital-treated group (re [extinction rate] = 0.0615 pmol/min) and the control group (re = 0.0549 pmol/min). The appearance rate of 1,25-(OH)2D3 was virtually the same in the treated group (ra [appearance rate] = 0.0133 pmol/min) and the control group (ra = 0.0134 pmol/min). Probably, phenobarbital does not affect the biotransformation of 25-OHD3 to 1,25-(OH)2D3 and altered vitamin D metabolism does not account for phenobarbital-induced osteomalacia.

引用

页码：393 / 398

页数：6

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