INTERFERON-GAMMA MESSENGER-RNA EXPRESSION UPON INVITRO LYMPHOCYTE-T ACTIVATION IS DECREASED IN RHEUMATOID-ARTHRITIS PATIENTS

被引：16

作者：

SADOUK, M ^{[2
]}

VAQUERO, C

DELATOUR, B

AMOR, B

TOUBERT, A

机构：

[1] HOP COCHIN,RHEUMATOL CLIN,F-75674 PARIS 14,FRANCE

[2] HOP COCHIN,INSERM,U152,F-75674 PARIS 14,FRANCE

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1990年 / 56卷 / 01期

关键词：

D O I：

10.1016/0090-1229(90)90167-O

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A decreased production of interferon-γ (IFN-γ) and interleukin-2 (IL-2) upon in vitro stimulation by phytohemagglutinin (PHA) peripheral blood leucocyte in active rheumatoid arthritis (RA) patients has been described as an important immunological abnormality in this disease. However, the molecular level at which this defect might occur has not been fully documented. We have investigated the kinetics of IFN-γ, interleukin-2 receptor (IL-2 R), and interleukin-1 β (IL-1 β) messenger RNA (mRNA) expression in RA patients (n = 9) and normal controls (n = 5) after PHA leucocyte activation. We demonstrate here a significantly decreased expression of IFN-γ mRNA in RA patients without modification of its kinetics associated with a similar IL-1 β mRNA expression. © 1990.

引用

页码：37 / 45

页数：9

共 35 条

[1] THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].

ARNETT, FC ;

EDWORTHY, SM ;

BLOCH, DA ;

MCSHANE, DJ ;

FRIES, JF ;

COOPER, NS ;

HEALEY, LA ;

KAPLAN, SR ;

LIANG, MH ;

LUTHRA, HS ;

MEDSGER, TA ;

MITCHELL, DM ;

NEUSTADT, DH ;

PINALS, RS ;

SCHALLER, JG ;

SHARP, JT ;

WILDER, RL ;

HUNDER, GG .

ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324

[2]

BROWNING JL, 1987, J IMMUNOL, V138, P2857

[3]

BUCHAN G, 1988, CLIN EXP IMMUNOL, V73, P449

[4]

BUCHAN G, 1988, CLIN EXP IMMUNOL, V71, P295

[5]

CANNON G W, 1989, Arthritis and Rheumatism, V32, pS130

[6]

CARPENTER A B, 1988, Arthritis and Rheumatism, V31, pS23

[7]

CATHELY G, 1986, CLIN RHEUMATOL, V5, P482

[8]

COMBE B, 1985, CLIN EXP IMMUNOL, V59, P520

[9] DEFICIENCY OF THE SUPPRESSOR INDUCER SUBSET OF LYMPHOCYTES-T IN RHEUMATOID-ARTHRITIS [J].

EMERY, P ;

GENTRY, KC ;

MACKAY, IR ;

MUIRDEN, KD ;

ROWLEY, M .

ARTHRITIS AND RHEUMATISM, 1987, 30 (08) :849-856

[10] STIMULATION-DEPENDENT LYMPHOKINE MESSENGER-RNA LEVELS IN HUMAN MONONUCLEAR-CELLS [J].

GAUCHAT, JF ;

WALKER, C ;

DEWECK, AL ;

STADLER, BM .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1988, 18 (09) :1441-1446

← 1 2 3 4 →