STRUCTURAL FEATURES OF POLYSACCHARIDES THAT INDUCE INTRAABDOMINAL ABSCESSES

被引：221

作者：

TZIANABOS, AO

ONDERDONK, AB

ROSNER, B

CISNEROS, RL

KASPER, DL

机构：

[1] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115

[3] HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,DIV INFECT DIS,BOSTON,MA 02215

来源：

SCIENCE | 1993年 / 262卷 / 5132期

关键词：

D O I：

10.1126/science.8211161

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The capsular polysaccharide complex from Bacteroides fragilis promotes the formation of intra-abdominal abscesses-a pathologic host response to infecting microorganisms. This complex consists of two distinct polysaccharides, each with repeating units that have positively charged amino groups and negatively charged carboxyl or phosphate groups. Analysis of these polysaccharides as well as other charged carbohydrates before and after chemical modification revealed that these oppositely charged groups are required for the induction of intra-abdominal abscesses in a rat model.

引用

页码：416 / 419

页数：4

共 22 条

[1] STRUCTURAL ELUCIDATION OF 2 CAPSULAR POLYSACCHARIDES FROM ONE STRAIN OF BACTEROIDES-FRAGILIS USING HIGH-RESOLUTION NMR-SPECTROSCOPY
BAUMANN, H
TZIANABOS, AO
BRISSON, JR
KASPER, DL
JENNINGS, HJ
[J]. BIOCHEMISTRY, 1992, 31 (16) : 4081 - 4089
[2] BHATTACHARJEE AK, 1975, J BIOL CHEM, V250, P1926
[3] ANAEROBIC INFECTIONS .1.
GORBACH, SL
BARTLETT, JG
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1974, 290 (21) : 1177 - 1184
[4] HEYNS K., 1967, CARBOHYD RES, V3, P340, DOI 10.1016/S0008-6215(00)82210-7
[5] STRUCTURE OF THE COMPLEX POLYSACCHARIDE C-SUBSTANCE FROM STREPTOCOCCUS-PNEUMONIAE TYPE-1
JENNINGS, HJ
LUGOWSKI, C
YOUNG, NM
[J]. BIOCHEMISTRY, 1980, 19 (20) : 4712 - 4719
[6] JENNINGS HJ, 1985, J IMMUNOL, V134, P2651
[7] STRUCTURE OF NATIVE POLYSACCHARIDE ANTIGENS OF TYPE-IA AND TYPE-IB GROUP-B STREPTOCOCCUS
JENNINGS, HJ
KATZENELLENBOGEN, E
LUGOWSKI, C
KASPER, DL
[J]. BIOCHEMISTRY, 1983, 22 (05) : 1258 - 1264
[8] IMMUNOCHEMICAL CHARACTERIZATION OF OUTER MEMBRANE COMPLEX OF BACTEROIDES-FRAGILIS SUBSPECIES FRAGILIS
KASPER, DL
SEILER, MW
[J]. JOURNAL OF INFECTIOUS DISEASES, 1975, 132 (04) : 440 - 450
[9] CAPSULAR POLYSACCHARIDES AND LIPOPOLYSACCHARIDES FROM 2 BACTEROIDES-FRAGILIS REFERENCE STRAINS - CHEMICAL AND IMMUNOCHEMICAL CHARACTERIZATION
KASPER, DL
WEINTRAUB, A
LINDBERG, AA
LONNGREN, J
[J]. JOURNAL OF BACTERIOLOGY, 1983, 153 (02) : 991 - 997
[10] STRUCTURAL STUDIES OF THE CAPSULAR POLYSACCHARIDE FROM STREPTOCOCCUS-PNEUMONIAE TYPE-1
LINDBERG, B
LINDQVIST, B
LONNGREN, J
POWELL, DA
[J]. CARBOHYDRATE RESEARCH, 1980, 78 (01) : 111 - 117

← 1 2 3 →