A GENERAL-MODEL OF CARCINOGENESIS .1. TUMOR EVOLUTION AND GENE DELETION

被引：13

作者：

CHIGIRA, M

机构：

[1] Department of Orthopedic Surgery, Gunma University, School of Medicine, Maebashi, Gunma, 371

来源：

MEDICAL HYPOTHESES | 1993年 / 40卷 / 04期

关键词：

D O I：

10.1016/0306-9877(93)90045-R

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Carcinogenesis is functionally a deletion alteration rather than addition of genetic information. Repressor genes may be more sensitive to 'neutral' mutations of DNA than those of structural genes, since selection pressure for deletion of repressors is extremely low in multicellular organisms. Dysfunction of repressors caused by genomic mutation induces autonomic expression of structural genes which is programmed a priori in each cell. Tumor progression can be explained by this deletion model with abnormal DNA repair. Alteration of DNA repairing units may be the initial mutation in carcinogenesis.

引用

页码：223 / 226

页数：4

共 32 条

[1]

[Anonymous], 1987, MOL EVOLUTIONARY GEN, DOI DOI 10.7312/NEI-92038

[2]

BASSIN RH, 1987, ADV VIRAL ONCOL, V6, P103

[3] DNA-REPAIR IN AN ACTIVE GENE - REMOVAL OF PYRIMIDINE DIMERS FROM THE DHFR GENE OF CHO CELLS IS MUCH MORE EFFICIENT THAN IN THE GENOME OVERALL [J].