EVALUATION OF THE ACUTE TOXICITY, ANALGESIC AND CNS ACTIVITIES OF DIFFERENT SPECIES OF TEUCRIUM GENUS

被引：18

作者：

BELLO, R

BARRACHINA, MD

MARTINEZCUESTA, MA

ESPLUGUES, J

YUFERA, EP

机构：

[1] UNIV VALENCIA,FAC MED & ODONTOL,DEPT FARMACOL,E-46100 VALENCIA,SPAIN

[2] UNIV POLITECN VALENCIA,CSIC,INST TECNOL QUIM,E-46071 VALENCIA,SPAIN

来源：

PHYTOTHERAPY RESEARCH | 1995年 / 9卷 / 04期

关键词：

TEUCRIUM CARTAGINENSES EXTRACTS; TEUCRIUM BUXIFOLIUM EXTRACTS; TEUCRIUM PUMILLUM EXTRACTS; TEUCRIUM FLAVUM EXTRACTS; EFFECTS ON CNS; ANALGESIA;

D O I：

10.1002/ptr.2650090409

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Methanol and dichloromethanol extracts of the leaves and stems of four Teucrium species (T. cartaginenses, T. flavum, T. pumillum and T. buxifolium) have been tested for their toxicity, analgesic and central depressor effects. The intraperitoneal administration of the different extracts showed a CNS depressant activity in mice, but they lacked anticonvulsive effects. When tested for analgesic activity none of the extracts increased the threshold of pain thermal stimulus. However, the methanol and dichloromethanol extracts of T. cartaginenses and T. buxifolium species showed a significant analgesic effect in models of pain induced by chemical or mechanical stimulation.

引用

页码：277 / 280

页数：4

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