CLONING OF THE RAT GADD45 CDNA AND ITS MESSENGER-RNA EXPRESSION IN THE BRAIN

被引：17

作者：

YOSHIDA, T

SCHNEIDER, EL

MORI, N

机构：

[1] UNIV SO CALIF,ETHEL PERCY ANDRUS GERONTOL CTR,DIV NEUROGERONTOL,LOS ANGELES,CA 90089

[2] UNIV SO CALIF,ETHEL PERCY ANDRUS GERONTOL CTR,DEPT SCI BIOL,LOS ANGELES,CA 90089

来源：

GENE | 1994年 / 151卷 / 1-2期

关键词：

RECOMBINANT DNA; IN VIVO; RNA TRANSCRIPTS; GROWTH ARREST INDUCIBLE; DNA-DAMAGE INDUCIBLE; GAMMA-RAY IRRADIATION; 28S RIBOSOMAL RNA;

D O I：

10.1016/0378-1119(94)90666-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We cloned the rat Gadd45 (growth arrest and DNA damage inducible) cDNA. and examined its mRNA induction by gamma-ray irradiation in the rat brain. The rat Gadd45 cDNA sequence was highly homologous to the previously published human and hamster cDNAs, and was partially similar to the 28S rRNA gene. The mRNA encoding rat GADD45 was induced in the brain after gamma-ray irradiation. This finding indicates that Gadd45 is an inducible gene following the ionizing radiation, not only in cultured cells in vitro, but also in animal tissues in vivo.

引用

页码：253 / 255

页数：3

共 5 条

[1]

HOLLANDER MC, 1993, J BIOL CHEM, V268, P24385

[2] A MAMMALIAN-CELL CYCLE CHECKPOINT PATHWAY UTILIZING P53 AND GADD45 IS DEFECTIVE IN ATAXIA-TELANGIECTASIA [J].