CD40 LIGAND IS FUNCTIONALLY EXPRESSED ON HUMAN EOSINOPHILS

被引：121

作者：

GAUCHAT, JF

HENCHOZ, S

FATTAH, D

MAZZEI, G

AUBRY, JP

JOMOTTE, T

DASH, L

PAGE, K

SOLARI, R

ALDEBERT, D

CAPRON, M

DAHINDEN, C

BONNEFOY, JY

机构：

[1] GLAXO INST MOLEC BIOL,DEPT IMMUNOL,CH-1228 PLAN LES OUATES,SWITZERLAND

[2] GLAXO RES & DEV,GREENFORD,MIDDX,ENGLAND

[3] INST PASTEUR,F-59019 LILLE,FRANCE

[4] UNIV BERN,INSELSPITAL,CH-3010 BERN,SWITZERLAND

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1995年 / 25卷 / 03期

关键词：

B CELLS; CD40; LIGAND; EOSINOPHILS; PROLIFERATION;

D O I：

10.1002/eji.1830250335

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD40 ligand (CD40L), a surface molecule which can be expressed by T cells, mast cells and basophils, has been shown to be involved in the control of B cell proliferation, immunoglobulin class switching as well as in the activation of monocytes and T cells. We demonstrate that CD40L can also be expressed constitutively by eosinophils from an hypereosinophilic patient or, upon activation, by the eosinophilic cell line EOL-3 and normal blood eosinophils. Eosinophils were able to induce, in conjunction with IL-4, CD40L-dependent B cell proliferation in vitro. These results suggest that CD40L could play a role in the inflammatory processes during which eosinophil infiltration and activation are observed.

引用

收藏

页码：863 / 865

页数：3

相关论文

共 15 条

[1] CD40 EXPRESSION BY HUMAN MONOCYTES - REGULATION BY CYTOKINES AND ACTIVATION OF MONOCYTES BY THE LIGAND FOR CD40 [J].

ALDERSON, MR ;

ARMITAGE, RJ ;

TOUGH, TW ;

STROCKBINE, L ;

FANSLOW, WC ;

SPRIGGS, MK .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (02) :669-674

[2] MOLECULAR AND BIOLOGICAL CHARACTERIZATION OF A MURINE LIGAND FOR CD40 [J].

ARMITAGE, RJ ;

FANSLOW, WC ;

STROCKBINE, L ;

SATO, TA ;

CLIFFORD, KN ;

MACDUFF, BM ;

ANDERSON, DM ;

GIMPEL, SD ;

DAVISSMITH, T ;

MALISZEWSKI, CR ;

CLARK, EA ;

SMITH, CA ;

GRABSTEIN, KH ;

COSMAN, D ;

SPRIGGS, MK .

NATURE, 1992, 357 (6373) :80-82

[3] CD40 LIGAND IS A T-CELL GROWTH-FACTOR [J].

ARMITAGE, RJ ;

TOUGH, TW ;

MACDUFF, BM ;

FANSLOW, WC ;

SPRIGGS, MK ;

RAMSDELL, F ;

ALDERSON, MR .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (09) :2326-2331

[4]

COCKS BG, 1993, INT IMMUNOL, V6, P657

[5] PREVENTION OF COLLAGEN-INDUCED ARTHRITIS WITH AN ANTIBODY TO GP39, THE LIGAND FOR CD40 [J].

DURIE, FH ;

FAVA, RA ;

FOY, TM ;

ARUFFO, A ;

LEDBETTER, JA ;

NOELLE, RJ .

SCIENCE, 1993, 261 (5126) :1328-1330

[6] HUMAN CD40-LIGAND - MOLECULAR-CLONING, CELLULAR-DISTRIBUTION AND REGULATION OF EXPRESSION BY FACTORS CONTROLLING IGE PRODUCTION [J].

GAUCHAT, JF ;

AUBRY, JP ;

MAZZEI, G ;

LIFE, P ;

JOMOTTE, T ;

ELSON, G ;

BONNEFOY, JY .

FEBS LETTERS, 1993, 315 (03) :259-266

[7] INDUCTION OF HUMAN IGE SYNTHESIS IN B-CELLS BY MAST-CELLS AND BASOPHILS [J].

GAUCHAT, JF ;

HENCHOZ, S ;

MAZZEI, G ;

AUBRY, JP ;

BRUNNER, T ;

BLASEY, H ;

LIFE, P ;

TALABOT, D ;

FLORESROMO, L ;

THOMPSON, J ;

KISHI, K ;

BUTTERFIELD, J ;

DAHINDEN, C ;

BONNEFOY, JY .

NATURE, 1993, 365 (6444) :340-343

[8] CLONING OF TRAP, A LIGAND FOR CD40 ON HUMAN T-CELLS [J].

GRAF, D ;

KORTHAUER, U ;

MAGES, HW ;

SENGER, G ;

KROCZEK, RA .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (12) :3191-3194

[9] PURIFICATION OF HUMAN-BLOOD EOSINOPHILS BY NEGATIVE SELECTION USING IMMUNOMAGNETIC BEADS [J].

HANSEL, TT ;

POUND, JD ;

PILLING, D ;

KITAS, GD ;

SALMON, M ;

GENTLE, TA ;

LEE, SS ;

THOMPSON, RA .

JOURNAL OF IMMUNOLOGICAL METHODS, 1989, 122 (01) :97-103

[10] THE HUMAN T-CELL ANTIGEN GP39, A MEMBER OF THE TNF GENE FAMILY, IS A LIGAND FOR THE CD40 RECEPTOR - EXPRESSION OF A SOLUBLE FORM OF GP39 WITH B-CELL COSTIMULATORY ACTIVITY [J].

HOLLENBAUGH, D ;

GROSMAIRE, LS ;

KULLAS, CD ;

CHALUPNY, NJ ;

BRAESCHANDERSEN, S ;

NOELLE, RJ ;

STAMENKOVIC, I ;

LEDBETTER, JA ;

ARUFFO, A .

EMBO JOURNAL, 1992, 11 (12) :4313-4321