PROLONGED SURVIVAL OF MICE WITH HUMAN GASTRIC-CANCER TREATED WITH AN ANTI-C-ERBB-2 MONOCLONAL-ANTIBODY

被引：28

作者：

OHNISHI, Y

NAKAMURA, H

YOSHIMURA, M

TOKUDA, Y

IWASAWA, M

UEYAMA, Y

TAMAOKI, N

SHIMAMURA, K

机构：

[1] TOKAI UNIV,SCH MED,DEPT PATHOL,ISEHARA,KANAGAWA 25911,JAPAN

[2] TOKAI UNIV,SCH MED,DEPT SURG,ISEHARA,KANAGAWA 25911,JAPAN

[3] CENT INST EXPTL ANIM,MIYAMAE KU,KAWASAKI,KANAGAWA 216,JAPAN

[4] MITSUBISHI CHEM CORP,YOKOHAMA RES CTR,AOBA KU,YOKOHAMA,KANAGAWA 227,JAPAN

[5] KANAGAWA ACAD SCI & TECHNOL,TAKATSU KU,KAWASAKI,KANAGAWA 213,JAPAN

来源：

BRITISH JOURNAL OF CANCER | 1995年 / 71卷 / 05期

关键词：

C-ERBB-2; SCID MOUSE; HUMAN GASTRICARCINOMA; MONOCLONAL ANTIBODY; IMMUNOTHERAPY;

D O I：

10.1038/bjc.1995.187

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A monoclonal antibody (MAb), 4D5, specifically recognising an extracellular epitope of the c-ErbB-2 protein, inhibited the growth of human gastric cancer overexpressing c-ErbB-2 severe combined immunodeficient (SCID) mice. This antibody also reduced the mass of established tumours xenografted into SCID mice, whereas gastric cancer not expressing c-ErbB-2 exhibited no regression in response to 4D5 treatment. In addition, administration of 4D5 prevented colonisation of cancer cells and prolonged the survival of host SCID mice inoculated i.v. with c-ErbB-2-overexpressing tumour cells. This is the first reported study to show that treatment with a single antibody specific to c-ErbB-2 prolongs the survival of host SCID mice bearing xenotransplanted tumours.

引用

页码：969 / 973

页数：5

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