AN OPTICALLY PURE 1,4-DIHYDROPYRIDINE FROM A RESOLUTION CATALYZED BY RABBIT LIVER ESTERASE

被引：12

作者：

REEVE, CD

CROUT, DHG

COOPER, K

FRAY, MJ

机构：

[1] UNIV WARWICK, DEPT CHEM, COVENTRY CV4 7AL, W MIDLANDS, ENGLAND

[2] PFIZER LTD, SANDWICH CT13 9NJ, KENT, ENGLAND

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0957-4166(00)80520-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The kinetic resolution of a precursor ef the dihydropyridine UK-74,505, 1, an antagonist of platelet activating factor, is described, in which rabbit liver esterase was used to catalyse the hydrolysis of an ester function linked to the chiral centre via a spacer arm of appropriate length.

引用

页码：785 / 794

页数：10

共 20 条

[1] ENZYMATIC RESOLUTION OF METHYL 2-ALKYL-2-ARYLACETATES [J].