IMPAIRED INSULIN RELEASE IN AGING RATS - METABOLIC AND IONIC EVENTS

被引：8

作者：

CASTRO, M ^{[1
]}

PEDROSA, D ^{[1
]}

OSUNA, JI ^{[1
]}

机构：

[1] UNIV GRANADA,FAC MED,DEPT MED,E-18012 GRANADA,SPAIN

来源：

EXPERIENTIA | 1993年 / 49卷 / 10期

关键词：

AGING; GLUCOSE UPTAKE; CALMODULIN; INSULIN RELEASE; PANCREATIC ISLETS;

D O I：

10.1007/BF01952596

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We investigated the effect of aging on glucose uptake, glucose-induced O2 consumption, glucose-induced Ca-45 movements, and calmodulin content to elucidate age-related impairment of glucose-induced insulin release in pancreatic islets of Wistar rats. Intact pancreatic islets from old (24-month-old) rats showed impaired glucose-induced insulin release; glucose uptake and O2 Consumption were lower in old than in young (2-month-old) or adult (12-month-old) rats. Moreover, Ca-45 uptake and calmodulin content were decreased in pancreatic islets from older rats, which explained the impairment in glucose-induced insulin release in aging. No major differences between the 3 age groups in glucose-induced Ca-45 efflux in pancreatic islets were observed.

引用

页码：850 / 853

页数：4

共 19 条

[1] THE ROLE OF OLD-AGE IN THE EFFECTS OF GLUCOSE ON INSULIN-SECRETION, PENTOSEPHOSPHATE SHUNT ACTIVITY, PYRIDINE-NUCLEOTIDES AND GLUTATHIONE OF RAT PANCREATIC-ISLETS [J].