INCREASE OF PLASMA ADRENOCORTICOTROPIN AND CORTISOL IN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP)-TREATED DOGS

被引：25

作者：

MIZOBUCHI, M ^{[1
]}

HINENO, T ^{[1
]}

KAKIMOTO, Y ^{[1
]}

HIRATANI, K ^{[1
]}

机构：

[1] EHIME UNIV, SCH MED, DEPT SURG 1, SHIGENOBU, EHIME 79102, JAPAN

来源：

BRAIN RESEARCH | 1993年 / 612卷 / 1-2期

关键词：

ADRENOCORTICOTROPIN; CORTISOL; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; PARKINSONS DISEASE; HYPOTHALAMUS; DOPAMINERGIC NEURON;

D O I：

10.1016/0006-8993(93)91678-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuroendocrine abnormality of the hypothalamic-pituitary-adrenal axis was investigated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated dogs as a model of Parkinson's disease. Blood samples were collected every 4 h for 3-4 days before MPTP treatment, around 2 and 4 weeks after the treatment of MPTP (2.5 mg/kg). Adrenocorticotrophin (ACTH) and cortisol concentrations in plasma were determined by radioimmunoassay. The concentrations of plasma ACTH and cortisol increased by 40% and 60% after MPTP treatment, respectively. Circadian rhythms of neither plasma ACTH nor cortisol concentrations were observed in both MPTP-treated and control dogs. This high hypothalamic-pituitary-adrenal function in MPTP-treated dogs suggests that MPTP may influence the activity of the hypothalamic neurons of the dog.

引用

页码：319 / 321

页数：3

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