AN INVESTIGATION OF THE ACTIVITIES OF 3-HYDROXYKYNURENINASE AND KYNURENINE AMINOTRANSFERASE IN THE BRAIN IN HUNTINGTONS-DISEASE

被引：13

作者：

PEARSON, SJ ^{[1
]}

MELDRUM, A ^{[1
]}

REYNOLDS, GP ^{[1
]}

机构：

[1] UNIV SHEFFIELD,DEPT BIOMED SCI,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1995年 / 102卷 / 01期

基金：

英国惠康基金;

关键词：

HUNTINGTONS DISEASE; TRYPTOPHAN KYNURENINE METABOLISM; POST MORTEM BRAIN; HPLC-ELECTROCHEMICAL DETECTION; 3-HYDROXYKYNURENINASE; KYNURENINE AMINOTRANSFERASE;

D O I：

10.1007/BF01276566

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous reports have indicated abnormalities in the concentrations of metabolites of the tryptophan/kynurenine pathway in the brain in Huntington's disease. These have included an increase in 3-hydroxykynurenine and both increases and decreases in kynurenic acid. The activities of two enzymes involved in the metabolism of these compounds, 3-hydroxykynureninase and kynurenine aminotransferase, have been determined in post mortem brain tissue taken from Huntington's disease patients and control subjects.

引用

页码：67 / 73

页数：7

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