PROTEIN ADSORPTION INVITRO ONTO BIOMATERIAL SURFACES COVERED WITH MULTI CARBON

被引：5

作者：

BOROVETZ, HS ^{[1
]}

MOLEK, GE ^{[1
]}

LEVINE, G ^{[1
]}

HARDESTY, RL ^{[1
]}

HAUBOLD, AD ^{[1
]}

机构：

[1] UNIV PITTSBURGH,SCH ENGN,PITTSBURGH,PA 15261

来源：

BIOMATERIALS MEDICAL DEVICES AND ARTIFICIAL ORGANS | 1982年 / 10卷 / 03期

关键词：

obtained in this end-use configuration supports the premise that the mode of protein adsorption and not necessarily the magnitude is a key factor. Caution; however; must be used when translating i n vitro data from a non-competitive adsorption study to the in vivo situation. Nevertheless the demonstrated hemocompatibility (14) of the ULTI carbon surfaced membrane oxygenator seen in animal model studies along with the current measurement of fibrinogen levels further substantiate the premise that fibrinogen levels can build to large values and not lead to a thrombogenic surface. ACKNOWLEDGEMENTS The authors wish to thank Professor Norman P. Curthoys for performing the studies of gel electrophoresis. The encouragement and support of Henry T. Bahnson M.D. are deeply appreciated. This research was supported in part by grant-in-aid awards from the Health Research and Services Foundation and Western Pennsylvania;

D O I：

10.3109/10731198209118780

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

引用

页码：187 / 203

页数：17

共 14 条

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