STEREOCHEMICAL STUDIES ON MEDICINAL AGENTS .19. X-RAY CRYSTAL-STRUCTURES OF 2 (+ OR -)-ALLYLPRODINE DIASTEREOMERS - ROLE OF ALLYL GROUP IN CONFERRING HIGH STEREOSELECTIVITY AND POTENCY AT ANALGETIC RECEPTORS

被引：16

作者：

PORTOGHESE, PS

SHEFTER, E

机构：

[1] UNIV MINNESOTA, COLL PHARM, DEPT MED CHEM, MINNEAPOLIS, MN 55455 USA

[2] SUNY Buffalo, SCH PHARM, BUFFALO, NY 14214 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1976年 / 19卷 / 01期

关键词：

D O I：

10.1021/jm00223a012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：55 / 57

页数：3

共 8 条

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[2] STEREOCHEMICAL STUDIES ON MEDICINAL AGENTS .17. SYNTHESIS, ABSOLUTE-CONFIGURATION, AND ANALGETIC POTENCY OF ENANTIOMERIC DIASTEREOMERS OF 3-ETHYL AND 3-PROPYL DERIVATIVES OF 1-METHYL-4-PHENYL-4-PROPIONOXYPIPERIDINE [J].

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[3] STEREOCHEMICAL STUDIES ON MEDICINAL AGENTS .15. ABSOLUTE-CONFIGURATIONS AND ANALGETIC POTENCIES OF ENANTIOMERIC DIASTEREOMERS OF 3-ALLYL-1-METHYL-4-PHENYL-4-PROPIONOXYPIPERIDINE [J].

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[4] STRUCTURAL STUDIES OF SYNTHETIC ANALGETICS .1. CRYSTAL AND MOLECULAR STRUCTURE OF (+/-)-GAMMA-PROMEDOL ALCOHOL [J].

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[5] STEREOCHEMICAL STUDIES ON MEDICINAL AGENTS .18. ABSOLUTE-CONFIGURATION AND ANALGETIC POTENCY OF TRIMEPERIDINE ENANTIOMERS [J].

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JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (09) :990-993

[6] THE CRYSTAL AND MOLECULAR STRUCTURE OF DL-ALPHAPRODINE HYDROCHLORIDE [J].

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[7] STEREOCHEMICAL STUDIES ON MEDICINAL AGENTS .12. DISTINCTION OF ENANTIOTOPIC GROUPS IN INTERACTION OF 1-METHYL-4-PHENYL-4-PROPIONOXYPIPERIDINE WITH ANALGETIC RECEPTORS [J].

LARSON, DL ;

PORTOGHESE, PS .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (03) :195-198

[8] STEREOCHEMICAL STUDIES ON MEDICINAL AGENTS .13. CORRELATION OF SOLID-STATE CONFORMATIONS OF 1,3,5-TRIMETHYL-4-PHENYL-4-PROPIONOXYPIPERIDINE AND 1,3-DIMETHYL-4-PHENYL-4-PROPIONOXYPIPERIDINE ENANTIOMERS WITH THEIR ABSOLUTE STEREOSELECTIVITY AT ANALGETIC RECEPTORS [J].

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GOMAA, ZSD ;

LARSON, DL ;

SHEFTER, E .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (03) :199-203

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