ATENOLOL IN DILATED CARDIOMYOPATHY - A CLINICAL INSTRUMENTAL STUDY

被引：8

作者：

MATTIOLI, AV

MODENA, MG

FANTINI, G

MATTIOLI, G

机构：

[1] Cattedra di Malattie Cardiovascolari, Universita' di Modena, Modena

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 1990年 / 4卷 / 02期

关键词：

atenolol; beta blockers; congestive heart failure; dilated cardiomyopathy;

D O I：

10.1007/BF01857761

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The usefulness of beta blockers in the treatment of congestive heart failure has been questioned. We selected 11 patients, mean age 47.1±13.8, affected by dilated cardiomyopathy in NYHA class III, who had been taking digoxin and diuretics for a long time. Atenolol 50 mg was added to conventional therapy. Both before and 3 months after treatment a clinical evaluation, chest x-ray, an exercise test, and an echocardiogram were performed. We observed an improvement of NYHA class in five patients. However, the exercise test showed no improvement: 2310±1299 vs. 2902±983 total kgm (ns). The echocardiogram showed improvements of the end-systolic diameter (from 6.3±1 cm to 5.9±0.8 cm; p<0.02), the fractional shortening (from 13.6±6.3% to 15.2±5.6%; p<0.05) the radius/thickness ratio (from 4.14±0.5 to 3.5±0.5; p<0.05), and the wall stress (from 208±49 g/cm2 to 163.5±41 g/cm2; p<0.02). The inotropic state index did not show any changes. We conclude that in some patients with dilated cardiomyopathy beta blockers may improve the clinical status and left ventricular performance. © 1990 Kluwer Academic Publishers.

引用

页码：505 / 507

页数：3

共 19 条

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