THE EFFECTS OF CLOMIPHENE CITRATE UPON OVULATION AND ENDOCRINOLOGY WHEN ADMINISTERED TO PATIENTS WITH UNEXPLAINED INFERTILITY

被引：20

作者：

RANDALL, JM

TEMPLETON, A

机构：

[1] Department of Obstetrics and Gynaecology, University of Aberdeen, Maternity Hospital, Aberdeen AB9 2ZD, Cornhill Road

来源：

HUMAN REPRODUCTION | 1991年 / 6卷 / 05期

关键词：

CLOMIPHENE; UNEXPLAINED INFERTILITY;

D O I：

10.1093/oxfordjournals.humrep.a137401

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Twenty-four couples with unexplained infertility were studied in a spontaneous cycle followed by a clomiphene citrate (CC) cycle (150 mg, days 5-9). All spontaneous cycles were ovulatory, as defined by follicular collapse determined by transvaginal sonography. In CC cycles, 6/24 (25%) cycles demonstrated luteinized unruptured follicles (LUF). In 2/6 LUF cycles there was no apparent luteinizing hormone (LH) surge. LUF cycles had significantly elevated LH levels in the follicular phase compared to ovulatory CC cycles. There was no apparent difference in serum oestradiol. In CC cycles multifollicular development occurred in 87.5% of cycles, with significantly elevated serum oestradiol. Luteinizing hormone and follicle-stimulating hormone were elevated in the follicular phase compared to spontaneous cycles. This study suggests a high incidence of LUF when CC is administered to ovulatory patients, and its use in patients with ovulatory infertility is questioned.

引用

页码：659 / 664

页数：6

共 37 条

[1]

Adashi E.Y., Clomiphene citrate-initiated ovulation: A clinical update, Semin. Reprod. Endocrinol, 4, pp. 255-276, (1986)

[2]

Archer D.F., Hofmann G., Brzyski R., Ross B., Scott R.T., Philput C.B., Oehninger S., Ware J.C., Effects of clomiphene citrate on episodic luteinizing hormone secretion throughout the menstrual cycle, Am, J. Obstet. Gynecol, 161, pp. 581-592, (1989)

[3]

Birkenfeld A., Beier H.M., Schenker J.G., The effect of clomiphene citrate on early embryonic dedvelopment, endometrium and implantation, Hum. Reprod, 1, pp. 387-395, (1986)

[4]

Chatterjee R., Chatterjee A., Blockade of ovulation by clomiphene citrate and its reversal by human chorionic gonadotrpin or prostaglandin F2 in rats, Prostaglandins Leukotrienes Med, 9, pp. 55-60, (1982)

[5]

Coulam C.B., Hill L.M., Breckle R., Ultrasonic evidence for luteinization of unruptured preovulatory follicles, Fertil. Steril, 37, pp. 524-529, (1982)

[6]

Dlugi A.M., Laufer N., Botero-Ruiz W., Dechemey A.H., Polan M., Haseltine F.B., Mezer H.C., Behrman H.R., Altered follicular development in clomiphene citrate versus human menopausal gonadotrophin-stimulated cycles for in vitro fertilization, Fertil. Steril, 43, pp. 40-47, (1985)

[7]

Dodson K.S., Macnaugton M.C., Coutts J., Infertility in women with apparent ovulatory cycles. II. The effects of clomiphene treatment on gonadotrophin and sex steroid hormones in peripheral plasma, Br, J. Obstet. Gynaecol, 82, pp. 625-633, (1975)

[8]

Eden J.A., Place J., Carter G.D., Jones J., Alaghband-Zadeh J., Pawson M.E., The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume, Obstet. Gynecol, 73, pp. 187-190, (1989)

[9]

Fedele L., Brioschi D., Marchini M., Dorta M., Parazzini F., Enhanced preovulatory progesterone levels in clomiphene citrate induced cycles, J. Clin. Endocrinol. Metab, 69, pp. 681-683, (1989)

[10]

Fleming R., Coutts J., Effects of clomiphene treatment on infertile women with normal menstrual rhythm, Br, J. Obstet. Gynaecol, 89, pp. 749-753, (1982)

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