PHENOTHIAZINES INHIBIT COLLAGEN-INDUCED THROMBOXANE-B2 SYNTHESIS AND INCREASE FORSKOLIN ANTI-AGGREGATING EFFECTS IN HUMAN PLATELETS

被引：6

作者：

ANFOSSI, G

MASSUCCO, P

MULARONI, E

CAVALOT, F

BURZACCA, S

MATTIELLO, L

TROVATI, M

机构：

[1] Department of Clinical and Biological Sciences, University of Turin, Ospedale S. Luigi Gonzaga, Orbassano, Torino

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1991年 / 22卷 / 05期

关键词：

D O I：

10.1016/0306-3623(91)90203-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The aim of the present study was to investigate the effects of phenothiazine compounds chlorpromazine and trifluoperazine on human platelet response to collagen and sodium arachidonate. 2. The results demonstrated that phenothiazines inhibit collagen-induced platelet aggregation and thromboxane B2 synthesis in a dose-dependent way and increase the antiaggregating properties of forskolin. 3. Phenothiazines at high concentrations decreased the platelet aggregation in response to arachidonate, without a significant reduction of thromboxane B2 production. 4. The data provides evidence that phenothiazine effects could involve calmodulin-dependent enzymatic activities.

引用

页码：773 / 778

页数：6

共 26 条

[1] AKTORIES K, 1985, PLATELETS PHYSL PHAR
[2] ANFOSSI G, 1990, ARCH INT PHARMACOD T, V307, P142
[3] ANFOSSI G, 1988, ARCH INT PHARMACOD T, V296, P144
[4] ARMITAGE P, 1971, STATISTICAL METHODS
[5] AGGREGATION OF BLOOD PLATELETS BY ADENOSINE DIPHOSPHATE AND ITS REVERSAL
BORN, GVR
[J]. NATURE, 1962, 194 (4832) : 927 - &
[6] EMANUELLI G, 1986, CLIN TRIALS J, V23, P178
[7] INSEL PA, 1982, J BIOL CHEM, V257, P7485
[8] JONES HP, 1985, PLATELETS PHYSL PHAR
[9] KATADA T, 1984, J BIOL CHEM, V259, P3568
[10] INHIBITORY EFFECT OF TRIFLUOPERAZINE ON AGGREGATION OF HUMAN-PLATELETS
KINDNESS, G
WILLIAMSON, FB
LONG, WF
[J]. THROMBOSIS RESEARCH, 1980, 17 (3-4) : 549 - 554

← 1 2 3 →