SUSCEPTIBILITIES OF NEISSERIA-GONORRHOEAE TO THE GLYCYLCYCLINES

被引：13

作者：

WHITTINGTON, WL

ROBERTS, MC

HALE, J

HOLMES, KK

机构：

[1] UNIV WASHINGTON,DEPT PATHOBIOL,SEATTLE,WA 98195

[2] CTR DIS CONTROL,ATLANTA,GA 30333

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 08期

关键词：

D O I：

10.1128/AAC.39.8.1864

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To assess the activities of two glycylcyclines, N,N-dimethylglycylamido (DMG) derivatives of minocycline (MINO) and 6-demethyl-6-deoxytetracycline (DMDOT), 203 gonococcal isolates recovered at six sexually transmitted disease clinics in the western United States were evaluated. Antimicrobial susceptibilities to tetracycline HCl, doxycycline, MINO, DMG-DMDOT, and DMG-MINO were determined by agar dilution tests. DMG-DMDOT and DMG-MINO were more active than tetracycline HCl, doxycycline, or MINO regardless of the presence of Tet M or of chromosomal mutations mediating tetracycline resistance (P < 0.001).

引用

页码：1864 / 1865

页数：2

共 9 条

[1] STANDARDIZATION OF DISK DIFFUSION AND AGAR DILUTION SUSCEPTIBILITY TESTS FOR NEISSERIA-GONORRHOEAE - INTERPRETIVE CRITERIA AND QUALITY-CONTROL GUIDELINES FOR CEFTRIAXONE, PENICILLIN, SPECTINOMYCIN, AND TETRACYCLINE [J].