ANTIBODIES TO BETA-ADRENERGIC RECEPTORS DISCLOSING AGONIST-LIKE PROPERTIES IN IDIOPATHIC DILATED CARDIOMYOPATHY AND CHAGAS HEART-DISEASE

被引：60

作者：

ROSENBAUM, MB ^{[1
]}

CHIALE, PA ^{[1
]}

SCHEJTMAN, D ^{[1
]}

LEVIN, M ^{[1
]}

ELIZARI, MV ^{[1
]}

机构：

[1] INST INVEST INGN GENET & BIOL MOLEC,BUENOS AIRES,ARGENTINA

来源：

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY | 1994年 / 5卷 / 04期

关键词：

SYMPATHETIC NERVOUS SYSTEM; CONGESTIVE HEART FAILURE; ADRENERGIC CARDIOMYOPATHY;

D O I：

10.1111/j.1540-8167.1994.tb01174.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antibodies to Beta-Adrenergic Receptors. Recent studies confirm the existence of antibodies (Abs) to beta-adrenoceptors in patients with idiopathic dilated cardiomyopathy and Chagas' heart disease. These Abs can be shown to exert both stimulatory and inhibitory effects, which may play a role in the development of the cardiac abnormalities known to occur in these diseases, including advanced heart failure. The hypothesis is advanced that Chagas' heart disease and some forms of idiopathic dilated cardiomyopathy may represent, at least partially, a form of ''adrenergic cardiomyopathy.''

引用

页码：367 / 375

页数：9

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