INVESTIGATION OF THE METABOLIC-FATE OF THE NEUROLEPTIC DRUG HALOPERIDOL BY CAPILLARY ELECTROPHORESIS ELECTROSPRAY-IONIZATION MASS-SPECTROMETRY

被引：44

作者：

TOMLINSON, AJ ^{[1
]}

BENSON, LM ^{[1
]}

JOHNSON, KL ^{[1
]}

NAYLOR, S ^{[1
]}

机构：

[1] MAYO CLIN,DEPT PHARMACOL,ROCHESTER,MN 55905

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 621卷 / 02期

关键词：

D O I：

10.1016/0378-4347(93)80101-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Combined capillary electrophoresis-mass spectrometry (CE-MS) is a powerful analytical tool for the characterization of components of complex mixtures. Furthermore, when interfaced with an electrospray ionization (ESI) source, skimmer induced fragmentation can yield structural information that aids compound identification. We show that these techniques can be used to probe the metabolic fate of drugs by investigation of the phase I metabolism of the widely used neuroleptic drug haloperidol. In addition, we demonstrate differences of in vitro metabolism of haloperidol by mouse and guinea pig hepatic microsomes.

引用

页码：239 / 248

页数：10

共 34 条

[1]

Baldessarini R.J., 1991, PHARMACOL BASIS THER, P383

[2]

FANG J, 1992, Medical Science Research, V20, P175

[3] DEHYDRATION IS THE 1ST STEP IN THE BIOACTIVATION OF HALOPERIDOL TO ITS PYRIDINIUM METABOLITE [J].