IN-SITU HYBRIDIZATION MAPPING OF A 500-KDA CALCIUM-SENSING PROTEIN GENE (LRP2) TO HUMAN-CHROMOSOME REGION 2Q31-]Q32.1 AND PORCINE CHROMOSOME REGION 15Q22-]Q24

被引：9

作者：

CHOWDHARY, BP

LUNDGREN, S

JOHANSSON, M

HJALM, G

AKERSTROM, G

GUSTAVSSON, I

RASK, L

机构：

[1] SWEDISH UNIV AGR SCI,DEPT CELL RES,S-75007 UPPSALA,SWEDEN

[2] UNIV UPPSALA HOSP,DEPT SURG,S-75185 UPPSALA,SWEDEN

来源：

CYTOGENETICS AND CELL GENETICS | 1995年 / 71卷 / 02期

关键词：

D O I：

10.1159/000134088

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recently, a 500-kDa protein, with homology to the rat Gp330 glycoprotein, was found to be expressed on the surface of human parathyroid, placental cytotrophoblast, and renal proximal tubule cells. The protein has been implicated to function as a sensor of extracellular calcium on parathyroid and placental cytotrophoblast cells. We report here in situ hybridization mapping of the corresponding gene, designated as low-density lipoprotein receptor related protein-2 and symbolized as LRP2, to human chromosome region 2q31→q32.1 and porcine chromosome region 15q22→q24. The results are discussed in a comparative mapping context. © 1995 S. Karger AG, Basel.

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页码：120 / 123

页数：4

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