THE INFLUENCE OF IBUPROFEN ON FRACTURE REPAIR - BIOMECHANICAL, BIOCHEMICAL, HISTOLOGIC, AND HISTOMORPHOMETRIC PARAMETERS IN RATS

被引：186

作者：

HUO, MH ^{[1
]}

TROIANO, NW ^{[1
]}

PELKER, RR ^{[1
]}

GUNDBERG, CM ^{[1
]}

FRIEDLAENDER, GE ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,DEPT ORTHOPAED & REHABIL,333 CEDAR ST,NEW HAVEN,CT 06510

来源：

JOURNAL OF ORTHOPAEDIC RESEARCH | 1991年 / 9卷 / 03期

关键词：

FRACTURE HEALING; BIOMECHANICS; IBUPROFEN; HISTOMORPHOMETRY; OSTEOCALCIN;

D O I：

10.1002/jor.1100090310

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Ibuprofen is a widely used cyclo-oxygenase inhibitor in clinical practice. It has been demonstrated by others to have an inhibitory effect on fracture repair in animals. In the present study, we were unable to demonstrate any significant alterations in fracture biomechanics as measured by torsion testing and fracture stage in mature Sprague-Dawley rats treated with 30 mg/kg/day oral dose of ibuprofen, starting 3 days following fracture, over a 12-week time interval. Fracture histology and serum osteocalcin levels were no different in treated animals than control animals. Furthermore, histomorphometric parameters of bone remodeling, including bone volume and bone formation rate in the intact tail vertebrae of these animals with unilateral femur fractures, were no different between treated and control animals.

引用

页码：383 / 390

页数：8

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