MEDIATION OF RESPONSES TO CALCIUM IN TASTE CELLS BY MODULATION OF A POTASSIUM CONDUCTANCE

被引：41

作者：

BIGIANI, AR ^{[1
]}

ROPER, SD ^{[1
]}

机构：

[1] UNIV COLORADO,HLTH SCI CTR,ROCKY MT TASTE & SMELL CTR,DENVER,CO 80262

来源：

SCIENCE | 1991年 / 252卷 / 5002期

关键词：

D O I：

10.1126/science.2011748

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Calcium salts are strong taste stimuli in vertebrate animals. However, the chemosensory transduction mechanisms for calcium are not known. In taste buds of Necturus maculosus (mud puppy), calcium evokes depolarizing receptor potentials by acting extracellularly on the apical ends of taste cells to block a resting potassium conductance. Therefore, divalent cations elicit receptor potentials in taste cells by modulating a potassium conductance rather than by permeating the cell membrane, the mechanism utilized by monovalent cations such as sodium and potassium ions.

引用

页码：126 / 128

页数：3

共 25 条

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