RECENT STUDIES OF RIBONUCLEASE-P

被引:152
作者
ALTMAN, S [1 ]
KIRSEBOM, L [1 ]
TALBOT, S [1 ]
机构
[1] UNIV UPPSALA, DEPT MICROBIOL, S-75105 UPPSALA, SWEDEN
关键词
TRANSFER RNA BIOSYNTHESIS; CATALYTIC RNA; RNA-PROTEIN INTERACTIONS; PHYLOGENETIC COMPARISONS;
D O I
10.1096/fasebj.7.1.7916700
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
RNase P is an essential enzyme that is required for the biosynthesis of tRNA. It is composed of RNA and protein subunits. The RNA subunit of the enzyme derived from eubacterial sources can carry out the catalytic function by itself in vitro. Current studies of RNase P focus on structure-function relationships with respect to interactions of the RNA subunit with its substrates and with respect to the determination of the kinetic parameters of the reaction, the role of the protein component, and the rules governing recognition of substrates.
引用
收藏
页码:7 / 14
页数:8
相关论文
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