THE PREVALENCE OF HELICOBACTER-PYLORI ANTIBODIES IN A POPULATION FROM SOUTHERN ESTONIA

被引：23

作者：

VOROBJOVA, T

KISAND, K

HAUKANOMM, A

MAAROOS, HI

WADSTROM, T

UIBO, R

机构：

[1] Laboratory of Immunology, Tartu University, Tartu

[2] Department of Medical Microbiology, Lund University, Lund

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 1994年 / 6卷 / 06期

关键词：

HELICOBACTER-PYLORI; EPIDEMIOLOGY; SEROLOGY; ENZYME-LINKED IMMUNOSORBENT ASSAY;

D O I：

10.1097/00042737-199406000-00014

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objectives: Previous retrospective histological studies have revealed a Helicobacter pylori infection rate of 73-79%. Cross-sectional studies on H. pylori prevalence are still lacking in Estonia. Design: A total of 1461 inhabitants between the ages of 15 and 95 years from the village of Karksi-Nuia and 497 between the ages of 50 and 91 years from Abja-Paluoja were examined for IgG antibodies to H. pylori. This study was performed on a quasi-global sample of the general adult rural population in two villages in southern Estonia. Method: A cell-surface glycine extract of H. pylori strain NCTC 11637 was used as antigen in an enzyme-linked immunosorbent assay. Results: IgG antibodies to H. pylori strain NCTC 11637 were detected in 87.0 +/- 2.3% of the inhabitants of Karksi-Nuia and in 89.3 +/- 3.6% of those from Abja-Paluoja. IgG prevalence rates increased from 69.0 +/- 9.5% in the 15- to 19-year-old age group to 83.0 +/- 7.1% in the 20- to 29-year-olds (P < 0.05). Conclusion: We found an extremely high prevalence rate of H. pylori infection in this Estonian adult rural population. H. pylori infection was very prevalent among young people (aged 15-29 years).

引用

页码：529 / 533

页数：5

共 40 条

[1]

Graham D.Y., Campylobacter pylori and peptic ulcer disease, Gastroenterology, 96, pp. 615-625, (1989)

[2]

Dooley C.P., Cohen H., Fitzgibbons P.L., Bauer M., Appleman M.D., Perez-Perez G.J., Et al., Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons, N Engl J Med, 321, pp. 1562-1566, (1989)

[3]

Parsonnet J., Friedman G.D., Vandersteen D.P., Chang Y., Vogelman J.H., Orentreich N., Et al., Helicobacter pylori infection and the risk of gastric carcinoma, N Engl J Med, 325, pp. 1127-1131, (1991)

[4]

Forman D., Helicobacter pylori infection and gastric carcinogenesis, Eur J Gastroenterol Hepatol, 4, pp. S31-S35, (1992)

[5]

Hedenbro J.L., Benoni C., Schalen C., Wadstrom T., Guruge J.L., Willen R., Et al., Helicobacter pylori and atrophic gastritis, Tokai J Exp Clin Med, 17, pp. 1-4, (1992)

[6]

Sipponen P., Seppala K., Gastric carcinoma: Failed adaptation to Helicobacter pylori, Scand J Gastroenterol, 27, pp. 33-38, (1992)

[7]

Solnick J.V., Tompkins L.S., : Helicobacter pylori and gastroduodenal disease: Pathogenesis and host-parasite interactions, Infect Agents Dis, 1, pp. 294-309, (1993)

[8]

Forman D., Webb P., Newell D., Coleman M., Palli D., Moller H., Et al., An international association between Helicobacter pylori infection and gastric cancer, Lancet, 341, pp. 1359-1362, (1993)

[9]

Guarner J., Mohar A., Parsonnet J., Halperin D., The association of Helicobacter pylori with gastric cancer and preneoplastic gastric lesions in Chiapas, Mexico, Cancer, 71, pp. 297-301, (1993)

[10]

Maaroos H.-I., Villako K., Sipponen P., Kekki M., Siurala M., Tammur R., Et al., Helicobacter pylori and chronic gastritis in a randomly selected adult population according to gastrobiopsy findings [in Russian], Archiv Patol, 10, pp. 9-11, (1990)

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