THROMBOSPONDIN AS A COMPONENT OF THE EXTRACELLULAR-MATRIX OF EPIRETINAL MEMBRANES - COMPARISONS WITH CELLULAR FIBRONECTIN

被引：20

作者：

HISCOTT, P

LARKIN, G

ROBEY, HL

ORR, G

GRIERSON, I

机构：

[1] MOORFIELDS EYE HOSP, INST OPHTHALMOL, DEPT CLIN, LONDON EC1U 9AT, ENGLAND

[2] MOORFIELDS EYE HOSP, VITREORETINAL UNIT, LONDON EC1V 9AT, ENGLAND

来源：

EYE | 1992年 / 6卷

关键词：

CELLULAR FIBRONECTIN; EPIRETINAL MEMBRANE; IMMUNOHISTOCHEMISTRY; PROLIFERATIVE VITREORETINOPATHY; PROLIFERATIVE DIABETIC RETINOPATHY; RETINA; THROMBOSPONDIN;

D O I：

10.1038/eye.1992.123

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

We compared the distribution of the adhesive extracellular matrix glycoproteins thrombospondin and cellular fibronectin in epiretinal membranes. A total of nine membranes were investigated with immunohistochemical techniques. Thrombospondin and cellular fibronectin immunoreactivity were observed in seven of the specimens and immunostaining for the two glycoproteins was co-localised in four of the membranes. The findings indicate that thrombospondin contributes to the extracellular glycoprotein content of epiretinal membranes and is frequently co-distributed with cellular fibronectin in the tissue. As a consequence, thrombospondin may play a role in the assembly of the extracellular matrix of epiretinal membranes.

引用

页码：566 / 569

页数：4

共 40 条

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