KINAFLUORENONE, A BENZO[B]FLUORENONE ISOLATED FROM THE KINAMYCIN PRODUCER STREPTOMYCES-MURAYAMAENSIS

被引：60

作者：

CONE, MC ^{[1
]}

MELVILLE, CR ^{[1
]}

GORE, MP ^{[1
]}

GOULD, SJ ^{[1
]}

机构：

[1] OREGON STATE UNIV,DEPT CHEM,CORVALLIS,OR 97331

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 05期

关键词：

D O I：

10.1021/jo00057a016

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A strain of Streptomyces murayamaensis blocked in the biosynthesis of the kinamycin antibiotics was obtained by nitrosoguanidine mutagenesis. The major colored metabolite of the mutant strain was characterized by NMR spectroscopy and X-ray crystallography as a benzo[b]fluorenone, the first of this class obtained from a natural source. A rationale is presented for kinafluorenone biogenesis and for its relationship to kinamycin biosynthesis.

引用

页码：1058 / 1061

页数：4

共 20 条

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