A BIOACTIVE FULLERENE PEPTIDE

被引：120

作者：

TONIOLO, C

BIANCO, A

MAGGINI, M

SCORRANO, G

PRATO, M

MARASTONI, M

TOMATIS, R

SPISANI, S

PALU, G

BLAIR, ED

机构：

[1] UNIV PADUA,CNR,CTR MECCANISMI REAZIONI ORGAN,DIPARTIMENTO CHIM ORGAN,I-35131 PADUA,ITALY

[2] UNIV TRIESTE,DIPARTIMENTO SCI FARMACEUT,I-34127 TRIESTE,ITALY

[3] UNIV FERRARA,DIPARTIMENTO SCI FARMACEUT,I-44100 FERRARA,ITALY

[4] UNIV FERRARA,DIPARTMENTO BIOCHIM & BIOL MOLEC,I-44100 FERRARA,ITALY

[5] UNIV PADUA,IST MICROBIOL,I-35100 PADUA,ITALY

[6] WELLCOME RES LABS,DEPT MOLEC SCI,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 26期

关键词：

D O I：

10.1021/jm00052a015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The highly hydrophobic C-60 (buckminsterfullerene) was water solubilized by covalently linking the synthon 1,2-dihydro-1,2-methanofullerene [60]-61-carboxylic acid to the alpha-amino group of the hydrophilic 4-8 sequence of peptide T, known to display potent human monocyte chemotaxis. The resulting compound, characterized by a variety of analytical techniques, including a UV spectrum in aqueous solution, exhibits remarkable chemotactic potency, comparable to that of the parent pentapeptide. Furthermore, this fullerene-peptide conjugate inhibits, albeit weakly, HIV-1 protease.

引用

页码：4558 / 4562

页数：5

共 38 条

[1] SYNTHESIS OF ALPHA-AMINO-ACID DERIVATIVES OF C-60 FROM 1,9-(4-HYDROXYCYCLOHEXANO)-BUCKMINSTERFULLERENE [J].