IMMUNE-RESPONSE OF CALVES TO FOOT-AND-MOUTH-DISEASE VIRUS-VACCINE EMULSIFIED WITH OIL ADJUVANT - STRATEGIES OF VACCINATION

被引：19

作者：

SPATH, EJA ^{[1
]}

SMITSAART, E ^{[1
]}

CASARO, APE ^{[1
]}

FONDEVILA, N ^{[1
]}

FERNANDEZ, F ^{[1
]}

LEUNDA, MR ^{[1
]}

COMPAIRED, D ^{[1
]}

BUFFARINI, M ^{[1
]}

PESSI, H ^{[1
]}

机构：

[1] INTA,CTR INVEST CIENCIAS VET,INST VIROL,RA-1708 BUENOS AIRES,DF,ARGENTINA

来源：

VACCINE | 1995年 / 13卷 / 10期

关键词：

FOOT-AND-MOUTH DISEASE; CALVES; VACCINATION; MATERNAL ANTIBODIES; IMMUNE RESPONSE;

D O I：

10.1016/0264-410X(95)00009-P

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Calves born to vaccinated cows under the regular annual vaccination programme were vaccinated at different ages using commercial quadrivalent (01, A79, A87 and C85 FMD V strains) vaccine emulsified in oil adjuvant. The antibody responses of vaccinated calves were evaluated using liquid-phase blocking sandwich ELISA. All calves 20, 30 and 40 clays old having high maternal antibody titres responded well to vaccination. Moreover, 25-57% of vaccinated calves showed protective antibody titres both at 90 and 120 days post-vaccination (d.p.v.), whereas none of the non-vaccinated animals achieved these levels. Calves aged 3-4 months with non-protective levels of colostral-derived antibodies responded with high antibody titres to vaccination which persisted for at least 4 months, In both groups of calves a certain degree of suppression of postvaccinal response was observed which was related to colostral antibody titres. Our results suggest that in order to reduce the proportion of calves susceptible to infection it is advisable to immunize calves as young as 20 days old to induce acceptable antibody titres for the following 4 months. In addition, a second vaccination 60 d.p.v. ensures high antibody levels in high disease risk areas.

引用

页码：909 / 914

页数：6

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