CEREBROSPINAL-FLUID CORTICOTROPIN AND CORTISOL ARE REDUCED IN INFANTILE SPASMS

被引:27
作者
BARAM, TZ
MITCHELL, WG
HANSON, RA
SNEAD, OC
HORTON, EJ
机构
[1] UNIV SO CALIF,DEPT NEUROL,LOS ANGELES,CA 90033
[2] UNIV SO CALIF,DEPT PEDIAT,LOS ANGELES,CA 90089
[3] CHILDRENS HOSP LOS ANGELES,DIV NEUROL,LOS ANGELES,CA 90027
[4] KAISER PERMANENTE,DEPT NEUROL,LOS ANGELES,CA
关键词
D O I
10.1016/0887-8994(95)00121-U
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Infantile spasms respond to ACTH, and levels of the hormone in cerebrospinal fluid of untreated infants with this disorder were found to be lower than in age-matched controls, In this study we analyzed cerebrospinal fluid cortisol and ACTH using improved immunoassays in a larger cohort of infants with infantile spasms, Analysis of 20 patients and 15 age-matched controls revealed significantly lower levels of both ACTH and cortisol in the cerebrospinal fluid, These data, combined with the efficacy of ACTH and glucocorticoids for infantile spasms, support an involvement of the brain-adrenal-axis in this disorder.
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页码:108 / 110
页数:3
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