HEPATITIS-E PROBABLY CONTRACTED VIA A CHINESE HERBAL MEDICINE, DEMONSTRATED BY NUCLEOTIDE SEQUENCING

被引：25

作者：

ISHIKAWA, K

MATSUI, K

MADARAME, T

SATO, S

OIKAWA, K

UCHIDA, T

机构：

[1] First Department of Internal Medicine, Iwate Medical University, Iwate, 020, 19-1 Uchimaru, Morioka

[2] Oikawa Clinic, Morioka

[3] Department of Pathology, Nihon University School of Medicine, Tokyo

来源：

JOURNAL OF GASTROENTEROLOGY | 1995年 / 30卷 / 04期

关键词：

HEPATITIS E; HEPATITIS E VIRUS; IMPORTED HEPATITIS; NUCLEOTIDE SEQUENCING;

D O I：

10.1007/BF02347574

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatitis E is endemic in developing countries and may occur as imported hepatitis in industrialized countries. A 46-year-old Japanese man developed immunoserologically diagnosed acute hepatitis E in japan 4 months after he had made a trip to China. He had bought a Chinese herbal medicine there, taking it occasionally until approximately 6 weeks prior to the onset of acute hepatitis. Nucleotide sequencing of the 3' terminal region of the viral cDNA amplified from the patient's serum by polymerase chain reaction revealed a high degree of homology (99.8% of 752 nucleotides) with the Chinese strain. Thus, the results of sequencing suggest that his hepatitis E was caused by infection with the Chinese strain, via the Chinese herbal medicine.

引用

页码：534 / 538

页数：5

共 15 条

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