ACYCLIC NUCLEOTIDES RELATED TO CLITOCINE - SYNTHESIS AND ANTI-HIV ACTIVITY

被引：12

作者：

FRANCHETTI, P ^{[1
]}

CAPPELLACCI, L ^{[1
]}

SHEIKHA, GA ^{[1
]}

GRIFANTINI, M ^{[1
]}

LOI, AG ^{[1
]}

DEMONTIS, A ^{[1
]}

SPIGA, MG ^{[1
]}

LACOLLA, P ^{[1
]}

机构：

[1] UNIV CAGLIARI, DIPARTIMENTO BIOL SPERIMENTALE, I-09124 CAGLIARI, ITALY

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1995年 / 14卷 / 3-5期

关键词：

D O I：

10.1080/15257779508012436

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The syntheses and antiviral activity of analogues of the anti-HIV agents PMEA, PMEDAP, (R)-PMPA, (R)-PMPDAP are described. In these analogues the adenine moiety is replaced by 4,6-diamino-5-nitro-pyrimidine (the aglycon of clitocine) or 2,4,6-triamino-5-nitro-pyrimidine. The synthesis of similar acyclic phosphonates related to PMEG and (R)-2'-methyl-PMEG is also reported. Some compounds proved to be active as anti-HIV agents.

引用

页码：607 / 610

页数：4

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