FERROCHELATASE BINDS THE IRON-RESPONSIVE ELEMENT PRESENT IN THE ERYTHROID 5-AMINOLEVULINATE SYNTHASE MESSENGER-RNA

被引：9

作者：

FERREIRA, GC

机构：

[1] UNIV S FLORIDA,INST BIOMOLEC SCI,TAMPA,FL 33612

[2] UNIV S FLORIDA,H LEE MOFFIT CANC CTR & RES INST,TAMPA,FL 33612

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 214卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.2368

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ferrochelatase, the terminal enzyme of the heme biosynthetic pathway, binds an iron-responsive element (IRE) present in the 5'untranslated region of the mRNA for erythroid 5-aminolevulinate synthase, the first enzyme of the heme biosynthetic pathway. This IRE-binding activity of ferrochelatase may play a critical role in the regulation of heme biosynthesis in differentiating erythrocytes. (C) 1995 Academic Press, Inc.

引用

页码：875 / 878

页数：4

共 21 条

[1] HUMAN DELTA-AMINOLEVULINATE SYNTHASE - ASSIGNMENT OF THE HOUSEKEEPING GENE TO 3P21 AND THE ERYTHROID-SPECIFIC GENE TO THE X-CHROMOSOME [J].