STRUCTURE OF HUMAN MONOCYTE CHEMOTACTIC PROTEIN GENE AND ITS REGULATION BY TPA

被引：118

作者：

SHYY, YJ

LI, YS

KOLATTUKUDY, PE

机构：

[1] OHIO STATE UNIV,OHIO STATE BIOTECHNOL CTR,CTR BIOMED ENGN,DEPT SURG,COLUMBUS,OH 43210

[2] OHIO STATE UNIV,MOLEC CELLULAR & DEV BIOL PROGRAM,COLUMBUS,OH 43210

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 169卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)90338-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Monocyte chemotactic protein released by endothelium plays an important role in inflammation, immune reactions and probably in atherogenesis. To elucidate the regulation of synthesis of this protein, the human gene encoding its synthesis was cloned and its nucleotide sequence was determined. This gene is composed of 3 exons of 145, 118 and 478 bp in length with 2 introns of 800 and 385 bp in length. Phorbol ester responsive elements (TRE) were found 129 and 157 bp upstream from the translation initiation site and the phorbol ester treatment of endothelial cell cultures elevated the transcript level of this gene. © 1990.

引用

页码：346 / 351

页数：6

共 15 条

[1] THE JUN PROTO-ONCOGENE IS POSITIVELY AUTOREGULATED BY ITS PRODUCT, JUN/AP-1 [J].