VITAMIN-A-DEFICIENCY AND GLUCOCORTICOID RECEPTOR ACTIVITY IN RAT-LIVER

被引：1

作者：

AUDOUIN, I

GARCIN, H

PAILLERRODDE, I

HIGUERET, P

机构：

[1] Laboratoire de Nutrition, ISTAB, Universite de Bordeaux I, 33405 Talence, Avenue des Facultes

来源：

JOURNAL OF ENDOCRINOLOGY | 1992年 / 133卷 / 02期

关键词：

D O I：

10.1677/joe.0.1330169

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The influence of vitamin A on the binding properties of hepatic glucocorticoid receptors (GR) was studied in young rats 7 weeks after they had been given a diet with or without vitamin A. Scatchard analysis showed an increased capacity of cytosolic GRs to bind dexamethasone in vitamin A deficiency. In these rats, an increase in tyrosine aminotransferase also occurred, and this could be related to the increased formation of hormone-GR complexes. Measurement of protein kinase C activity showed an increase which might be related to the functional activity of GRs.

引用

页码：169 / 173

页数：5

共 32 条

[1] EFFECTS OF CALF INTESTINAL ALKALINE-PHOSPHATASE, PHOSPHATASE INHIBITORS, AND PHOSPHORYLATED COMPOUNDS ON THE RATE OF ACTIVATION OF GLUCOCORTICOID-RECEPTOR COMPLEXES [J].