TURKEY MACROPHAGE AND HETEROPHIL BACTERICIDAL ACTIVITY AGAINST PASTEURELLA-MULTOCIDA

被引:39
作者
HARMON, BG [1 ]
GLISSON, JR [1 ]
NUNNALLY, JC [1 ]
机构
[1] UNIV GEORGIA,COLL VET MED,DEPT AVIAN MED,ATHENS,GA 30602
关键词
D O I
10.2307/1591559
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Bactericidal activity of turkey macrophages and heterophils was demonstrated in an in vitro colorimetric bactericidal assay. Two vaccine strains and one field isolate of Pasteurella multocida A:3,4 and a single isolate each of Escherichia coli and Staphylococcus aureus were compared for susceptibility to the bactericidal activity of turkey macrophages and heterophils. Only P. multocida A:3,4-strain M-9 (the least virulent strain) was susceptible to macrophage bactericidal activity in the absence of specific immune serum, whereas all three P. multocida A:3,4 organisms were killed when opsonized with specific immune serum. E. coli was susceptible to the bactericidal activity of macrophages, and S. aureus was resistant. All bacteria tested were highly sensitive to the bactericidal activity of intact turkey heterophils, regardless of the opsonin treatment. Electron microscopic findings suggested that heterophils may kill extracellular P. multocida. Only S. aureus and E. coli were killed by lysed heterophils.
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页码:986 / 991
页数:6
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