PNEUMOCANDINS FROM ZALERION-ARBORICOLA .1. DISCOVERY AND ISOLATION

被引：93

作者：

SCHWARTZ, RE

SESIN, DF

JOSHUA, H

WILSON, KE

KEMPF, AJ

GOKLEN, KA

KUEHNER, D

GAILLIOT, P

GLEASON, C

WHITE, R

INAMINE, E

BILLS, G

SALMON, P

ZITANO, L

机构：

[1] Merck Research Laboratories, N.J. 07065-0900

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 12期

关键词：

D O I：

10.7164/antibiotics.45.1853

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

HPLC bioautography of the directed biosynthesis of Zalerion arboricola led to the discovery of pneumocandin B0 (L-688,786), a new antifungal and anti-Pneumocystis carinii lipopeptide. Isolation techniques were developed to separate this component from pneumocandin A0 (L-671,329) in fermentations of a mutant of Zalerion arboricola. A number of related compounds were also isolated, which differ from pneumocandins A0 and B0 in the hydroxylation patterns on the ornithine, homotyrosine, and proline.

引用

页码：1853 / 1866

页数：14

共 21 条

[1] PNEUMOCANDINS FROM ZALERION-ARBORICOLA .5. GLUTAMIC ACID-DERIVED AND LEUCINE-DERIVED AMINO-ACIDS IN PNEUMOCANDIN A0(L-671,329) AND DISTINCT ORIGINS OF THE SUBSTITUTED PROLINE RESIDUES IN PNEUMOCANDINS A0 AND B0 [J].