BIOSYNTHESIS OF GRISEOLIC ACIDS - INCORPORATION OF C-13-LABELED COMPOUNDS INTO GRISEOLIC ACID A

被引:9
作者
MIYAKOSHI, S [1 ]
HARUYAMA, H [1 ]
SHIOIRI, T [1 ]
TAKAHASHI, S [1 ]
TORIKATA, A [1 ]
YAMAZAKI, M [1 ]
机构
[1] SANKYO CO LTD,ANALYT & METAB RES LABS,TOKYO 140,JAPAN
关键词
D O I
10.7164/antibiotics.45.394
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Biosynthesis of griseolic acids, competitive inhibitors of cyclic nucleotide phosphodiesterase, was investigated with the culture of a producing strain of Streptomyces griseoaurantiacus. C-13-Labeled and N-15-labeled compounds were added into the culture, and C-13-enriched and N-15-enriched griseolic acid A was isolated from the culture medium and analyzed by C-13 NMR and N-15 NMR spectroscopy. The compounds added to growth medium were [2-C-13]acetate, [1,2-C-13]acetate, [1,4-C-13]succinate, [1-C-13]glucose, [6-C-13]glucose, [2-C-13]ribose, and [1-C-13, N-15]glycine. The results suggest that adenosine, which is formed from amino acids and sugars contributes the adenine and ribose moieties to griseolic acid A. The data also suggest that a dicarboxylic acid from the Krebs tricarboxylic acid cycle contributes to the dicarboxylic part of the compound.
引用
收藏
页码:394 / 399
页数:6
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